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SMARCA4- , SMARCB1- and PBRM1-deficient cancer cells have low basal levels of GSH due to attenuated expression of SLC7A11 SLC7A11 Previously, we showed that ARID1A deficiency attenuated transcriptional expression of SLC7A11 , leading to low basal levels of GSH

However, the epigenetic memory effects of such interventions in germ cells, as well as their potential long-term impact on offspring safety, require systematic evaluation in preclinical and clinical settings

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